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HOU Baihe, LI Junjiao, CHEN Wei, ZHENG Xifu. The Research of An Unconditioned Stimulus Vicarious Retrieval on Reconsolidation of Fear Memory[J]. Journal of Modern Education, 2021, (1): 83-96.
Citation: HOU Baihe, LI Junjiao, CHEN Wei, ZHENG Xifu. The Research of An Unconditioned Stimulus Vicarious Retrieval on Reconsolidation of Fear Memory[J]. Journal of Modern Education, 2021, (1): 83-96.
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The Research of An Unconditioned Stimulus Vicarious Retrieval on Reconsolidation of Fear Memory

  • Received Date: 2021-10-20
    Available Online: 2021-07-16
    Abstract
  • The retrieval -extinction paradigm is one of the classic paradigms of memory reconsolidation, which is currently widely used in the current research on the extinction of fear memories. Compared with retrieve memory with conditioned stimulus (CS), the unconditioned stimulus (US) can activate more fear memory connections. However, in reality, the US may be difficult to replicate accurately, which limits its clinical application potential. Based on this, this study will present the US in a vicarious way (video), combined with the retrieval-extinction paradigm, to verify whether vicarious US retrieval methods can open up the reconsolidation of fear memories, thereby reducing fear responses. The results showed that neither the US retrieval-extinction group nor the vicarious US retrieval-extinction group showed spontaneous recovery and reinstatement of fear; however, the spontaneous recovery occurred when the extinction process was taken place immediately after vicarious US's retrieval. The result suggests that vicarious US retrieval can successfully reactivate the fear memory and destroy the original fear memory through the extinction training within the reconsolidation time window. However, it is necessary to leave an appropriate time interval between the retrieval and the extinction process.

     

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    • References(45)
  • [1]
    Milton, A. L., Holmes, E. A. Of mice and mental health:facilitating dialogue and seeing further[J]. Philosophical Transactions of the Royal Society B:Biological Sciences, 2018, 373(1742):20170022.
    [2]
    陈伟, 李俊娇, 林小裔, 张晓霞, 郑希付. 行为干预情绪记忆再巩固:从实验室到临床转化[J]. 心理科学进展, 2020, 28(2):240-251.
    [3]
    Loerinc, A. G., Meuret, A. E., Twohig, M. P., Rosenfield, D., Bluett, E. J., & Craske, M. G. Response rates for CBT for anxiety disorders:need for standardized criteria[J]. Clinical Psychology Review, 2015, 42:78-82.
    [4]
    Simpson, H. B., Huppert, J. D., Petkova, E., Foa, E. B., & Liebowitz, M. R. Response versus remission in obsessive-compulsive disorder[J]. The Journal of Clinical Psychiatry, 2006, 67(2):269-276.
    [5]
    Napier, R. M., Macrae, M., & Kehoe, E. J. Rapid reacquisition in conditioning of the rabbit's nictitating membrane response[J]. Journal of Experimental Psychology:Animal Behavior Processes, 1992, 18(2):182-192.
    [6]
    Millin, P. M., Moody, E. W., & Riccio, D. C. Interpretations of retrograde amnesia:old problems redux[J]. Nature reviews Neuroscience, 2001, 2(1):68-70.
    [7]
    Kroes, M. C. W., Tendolkar, I., Van Wingen, G. A., Van Waarde, J. A., Strange, B. A., & Fernández, G. An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans[J]. Nature Neuroscience, 2014, 17(2):204-206.
    [8]
    Monfils, M. H., Cowansage, K. K., Klann, E., & Ledoux, J. E. Extinction-reconsolidation boundaries:key to persistent attenuation of fear memories[J]. Science, 2009, 324(5929):951-955.
    [9]
    Schiller, D., Monfils, M. H., Raio, C. M., Johnson, D. C., Ledoux, J. E., & Phelps, E. A. Preventing the return of fear in humans using reconsolidation update mechanisms[J]. Nature, 2010, 463(7277):49-53.
    [10]
    陈伟, 李俊娇, 曹杨婧文, 杨勇, 胡琰健, 郑希付. 预期错误在复合恐惧记忆提取消退中的作用[J]. 心理学报, 2018, 50(7):739-749.
    [11]
    曹杨婧文, 李俊娇, 陈伟, 杨勇, 胡琰健, 郑希付. 条件性恐惧记忆消退的提取干预范式及其作用的神经机制[J]. 心理科学进展, 2019, 27(2):268-277.
    [12]
    Junjiao, L., Wei, C., Jingwen, C., Yanjian, H., Yong, Y., Liang, X., et al. Role of prediction error in destabilizing fear memories in retrieval extinction and its neural mechanisms[J]. Cortex, 2019, 121:292-307.
    [13]
    Li, J., Chen, W., Caoyang, J., Wu, W., Jie, J., Xu, L., & Zheng, X. Moderate Partially Reduplicated Conditioned Stimuli as Retrieval Cue Can Increase Effect on Preventing Relapse of Fear to Compound Stimuli[J]. Frontiers in human neuroscience, 2017, 11:575.
    [14]
    Daisuke, I., Daisuke, M., Shingo, M., Haruna, T., Chihiro, S., & Eiji, S. No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms[J]. Neuroscience Letters, 2012, 523(1):76-81.
    [15]
    Luyten, L., & Beckers, T. A preregistered, direct replication attempt of the retrieval-extinction effect in cued fear conditioning in rats[J]. Neurobiology of Learning and Memory, 2017, 144:208-215.
    [16]
    Kindt, M., & Soeter, M. Reconsolidation in a human fear conditioning study:a test of extinction as updating mechanism[J]. Biological Psychology, 2013, 92(1):43-50.
    [17]
    Wang, S. H., Lucas, D. O. A., & Nader, K. (2009). Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation[J]. Nature Neuroscience, 2009, 12(7):905-912.
    [18]
    Jones, C. E., Ringuet, S., & Monfils, M. H. Learned together, extinguished apart:reducing fear to complex stimuli[J]. Learning & Memory, 2013, 20(12):674-685.
    [19]
    Debiec, J., Doyere, V., Nader, K., & Ledoux, J. E. Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(9):3428-3433.
    [20]
    Liu, J., Zhao, L., Xue, Y., Shi, J., Suo, L., Luo, Y., et al. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory[J]. Biological psychiatry, 2014, 76(11):895-901.
    [21]
    Luo, Y. X., Xue, Y. X., Liu, J. F., Shi, H. S., Jian, M., Han, Y., et al. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking[J]. Nature communications, 2015, 6:7675.
    [22]
    Askew, C., & Field, A. P. The vicarious learning pathway to fear 40 years on[J]. Clinical Psychology Review, 2008, 28(7):1249-1265.
    [23]
    Seligman, L. D., Wuyek, L. A., Geers, A. L., Hovey, J. D., & Motley, R. L. The effects of inaccurate expectations on experiences with psychotherapy[J]. Cognitive Therapy & Research, 2009, 33(2):139-149.
    [24]
    Pineles, S. L., Orr, M. R., & Orr, S. P. An alternative scoring method for skin conductance responding in a differential fear conditioning paradigm with a long-duration conditioned stimulus[J]. Psychophysiology, 2009, 46:984-995.
    [25]
    Lykken, D. T. Range correction applied to heart rate and to GSR data[J]. Psychophysiology, 1972, 9(3):373-379.
    [26]
    Debiec, J., Díaz-Mataix L, Bush, D. E. A., Doyère, V., & LeDoux, J. E. The amygdala encodes specific sensory features of an aversive reinforcer[J]. Nature Neuroscience, 2010, 13(5):536-537.
    [27]
    Díaz-Mataix, L., Debiec, J., Ledoux, J. E., & Doyère, V. Sensory-specific associations stored in the lateral amygdala allow for selective alteration of fear memories[J]. Journal of Neuroscience, 2011, 31(26):9538-9543.
    [28]
    Thompson, A., & Lipp, O. V. (2017). Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli[J]. Behaviour Research and Therapy, 2017, 92:1-10.
    [29]
    Meir Drexler, S., Merz, C. J., Lissek, S., Tegenthoff, M., & Wolf, O. T. Reactivation of the Unconditioned Stimulus Inhibits the Return of Fear Independent of Cortisol[J]. Frontiers in behavioral neuroscience, 2019, 13:254.
    [30]
    Bouton, M. E. Context, ambiguity, and unlearning:sources of relapse after behavioral extinction[J]. Biological Psychiatry, 2002, 52(10):976-986.
    [31]
    Storsve, A. B., McNally, G. P., & Richardson, R. (2010). US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA dependent and subject to renewal and reinstatement[J]. Neurobiology of Learning and Memory, 2010, 93(4):463-471.
    [32]
    Rescorla, R. A. Effect of us habituation following conditioning[J]. Journal of Comparative & Physiological Psychology, 1973, 82(1):137-143.
    [33]
    Rescorla, R. A., & Heth, C. D. Reinstatement of fear to an extinguished conditioned stimulus[J]. Journal of Experimental Psychology:Animal Behavior Processes, 1975, 1(1):88-96.
    [34]
    Ledgerwood, L., Richardson, R., & Cranney, J. D-cycloserine and the facilitation of extinction of conditioned fear:consequences for reinstatement[J]. Behavioral Neuroscience. 2004, 118(3):505-513.
    [35]
    Soeter, M., & Kindt, M. Disrupting reconsolidation:pharmacological and behavioral manipulations[J]. Learning & memory, 2011, 18(6):357-366.
    [36]
    Dunbar, A. B., & Taylor, J. R. Reconsolidation and psychopathology:moving towards reconsolidation-based treatments[J]. Neurobiology of Learning and Memory, 2017, 142:162-171.
    [37]
    Chen, Q., Panksepp, J. B., & Lahvis, G. P. Empathy is moderated by genetic background in mice[J]. PLoS ONE, 2009, 4(2):e4387.
    [38]
    Jeon, D., Kim, S., Chetana, M., Jo, D., Ruley, H. E., Lin, S. Y., Rabah, D., Kinet, J. P., & Shin, H. S. Observational fear learning involves affective pain system and Cav1. 2 Ca2+ channels in ACC[J]. Nature neuroscience, 2010, 13(4):482-488.
    [39]
    Carrillo, M., Han, Y., Migliorati, F., Liu, M., Gazzola, V., & Keysers, C. Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex[J]. Current Biology, 2019, 29(8):1301-1312
    [40]
    Kleberg, J. L., Selbing, I., Lundqvist, D., Hofvander, B., & Olsson, A. Spontaneous eye movements and trait empathy predict vicarious learning of fear[J]. International Journal of Psychophysiology, 2015, 98(3):577-583.
    [41]
    Gonzalez-Liencres, C., Juckel, G., Tas, C., Friebe, A., & Brüne, M. Emotional contagion in mice:the role of familiarity[J]. Behavioural Brain Research, 2014, 263:16-21.
    [42]
    Pisansky, M. T., Hanson, L. R., Gottesman, I. I., & Gewirtz, J. C. Oxytocin enhances observational fear in mice[J]. Nature Communications, 2017, 8(1):2102.
    [43]
    Craske, M. G., Treanor, M., Conway, C. C., Zbozinek, T., & Vervliet, B. Maximizing exposure therapy:An inhibitory learning approach[J]. Behaviour Research and Therapy, 2014, 58:10-23.
    [44]
    Shiban, Y., Brütting, J., Pauli, P., & Mühlberger, A. Fear reactivation prior to exposure therapy:does it facilitate the effects of VR exposure in a randomized clinical sample[J]? Journal of Behavior Therapy and Experimental Psychiatry, 2015, 46:133-140.
    [45]
    Schiller, D., Raio, C. M., & Phelps, E. A. Extinction training during the reconsolidation window prevents recovery of fear[J]. Journal of visualized experiments, 2012, (66):e3893.
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