Abstract: The issue of "alignment of rules and mechanisms for the integrated development of education, science and technology, and talent in the Guangdong-Hong Kong-Macao Greater Bay Area" is, in essence, not only one of the specific matters that should be addressed as a priority in the integrated development of the Greater Bay Area, but also an inescapable and significant practical component of its construction. From the perspective of a basic research framework, the relevant concepts and knowledge of cross-domain governance theory can provide a scientific reference for analysing the institutional roots, change mechanisms, and future pathways of the insufficient alignment of rules and mechanisms in the "integrated advancement of education, science and technology, and talent" within the Greater Bay Area. For the longer-term research on the alignment of rules and mechanisms for the integrated advancement of education, science and technology, and talent in the Greater Bay Area, it is necessary to maintain a clear focus on the goal of theoretical knowledge production, to effectively serve the implementation of policies and practices, and take holistic account of the issue of global public goods in the field of "integrated advancement of education, science and technology, and talent".