无条件刺激替代提取对恐惧记忆再巩固的影响

侯百合; 李俊娇; 陈伟; 郑希付

无条件刺激替代提取对恐惧记忆再巩固的影响

基金项目:

国家自然科学基金项目（31970996）；国家社会科学基金重大项目（19ZDA360）；广东省哲学社会科学规划项目（GD19YXL01）

详细信息

作者简介:
侯百合,华南师范大学心理学院硕士研究生;李俊娇,广东第二师范学院教师教育学院讲师;陈伟,华南师范大学心理学院博士研究生

通讯作者:
郑希付(通讯作者),华南师范大学心理学院教授,E-mail:zhengxifu@m.scnu.edu.cn

中图分类号: G441;B842.2
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- 文章访问数: 391
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- 被引次数: 0
出版历程
- 收稿日期: 2021-10-20
- 网络出版日期: 2021-07-16

The Research of An Unconditioned Stimulus Vicarious Retrieval on Reconsolidation of Fear Memory

摘要

摘要: 提取消退范式是记忆再巩固经典范式之一，目前被广泛应用于当前的恐惧记忆的消退研究中。相比条件刺激（CS）提取记忆，无条件刺激（US）提取消退记忆的方法能够激活更多恐惧记忆联结。然而现实中US可能难以精确复制，这限制了其临床应用潜力。基于此本研究将用替代性的方式（视频）呈现US，与提取消退范式相结合，来考察替代性US提取方式能否开启恐惧记忆的再巩固，从而减少恐惧反应。结果显示US提取消退条件以及替代US提取消退条件均未出现恐惧的自发恢复和重建；替代US提取后立即消退条件出现了自发恢复。该结果提示替代性的US提取能够成功重新激活恐惧记忆，在再巩固时间窗内通过消退训练破坏原始恐惧记忆，但需要在提取后到消退之间留有恰当时间间隔。
- 无条件刺激提取 /
- 替代提取 /
- 提取消退 /
- 记忆再巩固 /
- 条件性恐惧
Abstract: The retrieval -extinction paradigm is one of the classic paradigms of memory reconsolidation, which is currently widely used in the current research on the extinction of fear memories. Compared with retrieve memory with conditioned stimulus (CS), the unconditioned stimulus (US) can activate more fear memory connections. However, in reality, the US may be difficult to replicate accurately, which limits its clinical application potential. Based on this, this study will present the US in a vicarious way (video), combined with the retrieval-extinction paradigm, to verify whether vicarious US retrieval methods can open up the reconsolidation of fear memories, thereby reducing fear responses. The results showed that neither the US retrieval-extinction group nor the vicarious US retrieval-extinction group showed spontaneous recovery and reinstatement of fear; however, the spontaneous recovery occurred when the extinction process was taken place immediately after vicarious US's retrieval. The result suggests that vicarious US retrieval can successfully reactivate the fear memory and destroy the original fear memory through the extinction training within the reconsolidation time window. However, it is necessary to leave an appropriate time interval between the retrieval and the extinction process.
- US-reactivation /
- vicarious retrieval /
- retrieval-extinction /
- memory reconsolidation /
- fear conditioning

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